| 3,550 | 209 | 421 |
| 下载次数 | 被引频次 | 阅读次数 |
天花粉为葫芦科植物栝楼或双边栝楼的干燥根,是我国临床上常用的一种中药材。主要含糖类、蛋白质、皂苷和氨基酸等有效成分,具有降血糖、终止妊娠、抗肿瘤、抗炎、抗病毒、抑菌和凝血等多种药理活性。就天花粉的有效成分及其药理活性进行综述,为天花粉的质量控制、药效药理及临床应用等后继工作的研究奠定基础和提供参考。
Abstract:[1]药典委员会.中国药典2010版一部(S).北京:中国医药科技出版社,2010.52.
[2]黄晓兰,吴惠勤,王蔚,等.天花粉多糖的单糖组成和相对分子质量的测定[J].中草药,2008,39(12):1810-1812.
[3]Shaw ang-Chui,Chan Wah-Lun,Yeung Hin-Wing,et al.Trichosanthin-A Protein With Multiple Pharmacological[J].Life Sciences,1994,55(4):253-262.
[4]Wang H.X,Ng T.B.Heterogeneity of the ribosome-inactivating protein trichosanthin in Trichosanthes kirilowii tubers[J].Comparative Biochemistry and Physiology Part B,2000,127:519-524.
[5]Pushpa Narayanan,Nai Ki Mak,Phuong Bich Luong,et al.Isolation and characterization of new isoforms of trichosanthin from Trichosanthes kirilowii[J].Plant Science,2002,162:79-85.
[6]Keyi-bao.Structure-function relationship of trichosanthin[J].Life sci,1997,60(7):465.
[7]Nishant Bhatia,Karen A.Mc Donald,Alan P.Jackman,and Abhaya M.Dandekar.A Simplified Procedure for the Purification of Trichosanthin(A Type 1 Ribosome Inactivating Protein)from Trichosanthes kirilowiiRoot Tubers[J].Protein Expression and Purifcation,1996,7,143-146.
[8]陈颖,董孝刚,孟丽,等.天花粉中总三萜皂苷的含量分析[J].中国野生植物资源,2010,29(4):61-63.
[9]潘建,陈文秋,余施筱,等.柱前衍生反相高效液相色谱法测定天花粉中γ-氨基丁酸含量[J].药物鉴定,2008,17(2):37-38.
[10]Wu AM,Wu JH,Tsai MS,Herp A.Carbohydrate specificity of an agglutinin isolated from the root of Trichosanthes kirilowii[J].Life Sci,2000,66(26):2571.
[11]刘伟,方磊,王晓.雌雄栝楼天花粉中6种元素次级形态分析研究[J].中药材,2012,35(3):421-423.
[12]Lei Cui,Jian Song,Liting Wu,et al.Smac is another pathway in the anti-tumour activity of Trichosanthin and reverses Trichosanthin resistance in Ca Ski cervical cancer cells Smac[J].Biomedicine&Pharmacotherapy,2015,69:119-124.
[13]宋华梅,黄利鸣,王艳林,等.天花粉蛋白对宫颈癌Caski细胞DNMT1基因的表达和酶活性的影响[J].中国药理学通报,2010,26(10):1312-1315.
[14]谭寒星,黄利鸣,王艳林,等.天花粉蛋白对子宫颈癌Hela细胞Survivin基因的影响[J].中华中医药杂志,2011,26(11):2702-2705.
[15]王英俊,张桂兰.天花粉蛋白对结肠癌细胞株SW-1116凋亡影响的体外研究[J].中医研究,2007,20(4):33-34.
[16]国敏.天花粉蛋白诱导胃癌细胞Lo Vo凋亡的实验研究[J].河南中医,2011,31(9):990.
[17]王英俊.天花粉蛋白对胃癌细胞株SGC-7901凋亡影响的体外研究[J].中国医药导报,2007,4(16):130-131.
[18]S.W.Tsno,K.T.YAN,H.W.YEUNG.Selective killing of choriocarcinoma cells in vitro by Trichosanthin,a plant protein purified from root tubers of the chinese medicinal herb Trichosanthes kirilowii[J].Toxtrnn 7A,1986,831-840.
[19]Dongxu He,Jian Jin,Yongtang Zheng,et al.Anti-angiogenesis effect of trichosanthin and the underlying mechanism[J].Biochemical and Biophysical Research Communications,2013,430:735-740.
[20]Yi Zu Jiao,Wang Yi Liu.Low-density lipoprotein receptor-related protein 1 is an essential receptor for trichosanthin in 2 choriocarcinoma cell lines[J].Biochemical and Biophysical Research Communications,2010,391:1579-1584.
[21]王建英,李勇,程建新,等.天花粉蛋白对绒癌细胞JEG-3体外增殖和HLA-G、HLA-E表达的影响[J].中国老年学杂志,2008,28:247-249.
[22]韩冰冰,李洁.天花粉蛋白对小鼠黑色素移植瘤血管生成拟态及PI3K表达的影响[J].中药药理与临床,2013,29(3):38-40.
[23]庄静,孙伟国,汪丛丛,等.天花粉蛋白对肺癌A549细胞JNK、Bcl-2蛋白表达的影响[J].中医杂志,2014,55(21):1864-1866.
[24]候贺佳,张爽.天花粉蛋白对卵巢癌HO8910细胞凋亡及Bax、Bcl-2基因表达的影响[J].辽宁中医杂志,2011,38(9):1729-1730.
[25]丁波泥,陈道瑾,李小荣,等.天花粉蛋白抑制乳腺癌生长的实验研究[J].实用肿瘤杂志,2008,23(4):310-313.
[26]曹丽莉,徐妍,徐水凌,等.天花粉多糖诱导人乳腺癌MCF-7细胞凋亡及其Caspase-3和Caspase-8活化对凋亡的影响[J].浙江大学学报,2012,41(5):529-534.
[27]Fenye Liu,Bing Wang,Zhixue Wang,et al.Trichosanthin down-regulates Notch signaling and inhibits proliferation of the nasopharyngeal carcinoma cell line CNE2 in vitro[J].Fitoterapia,2012,83:838-842.
[28]王媛媛,欧阳东云,郑永唐.天花粉蛋白体外抗人白血病和淋巴瘤细胞的作用机制[J].中国实验血液学杂志,2007,15(4):729-732.
[29]李琼,叶小利,陈新.天花粉降糖作用有效部位的研究[J].长春中医药大学学报,2012,8(1):9-11.
[30]戴良图,张华,王晨曦.天花粉蛋白治疗异位妊娠的临床应用及不良反应分析[J].军医学杂志,2013,34(5):321-324.
[31]Xiaorong Zhou,Neng Yang,Liming Lu,et al.Kuang-Yen Chou Up-regulation of IL-10 expression in dendritic cells is involved in Trichosanthin-induced immunosuppression[J].Immunology Letters,2007,110:74-81.
[32]Hong Zhou,Zhijun Jiao,Jijun Pan,et al.Immune suppression via IL-4/IL-10-secreting T cells:A nontoxic property of anti-HIV agent Trichosanthin[J].Clinical Immunology,2007,122:312-322.
[33]徐水凌,赵桂珠,屠婕红.天花粉多糖对人外周血单个核细胞的免疫活性作用[J].中国中药杂志,2010,35(6):745-748.
基本信息:
中图分类号:R284;R285
引用信息:
[1]冯果,陈娟,刘文,等.天花粉有效成分及药理活性研究进展[J].微量元素与健康研究,2015,32(06):59-62.
基金信息:
贵州省中药现代化科技产业研究开发专项(黔科合中药字2013-5049号);; 贵州省教育厅产学研基地(黔教合KY字2013-123号);; 贵州省大学生创业训练计划项目(201310662018);; 贵州省中药民族药炮制与制剂工程技术研究中心(黔科合重G字2012-4001号)
2015-09-11
2015-09-11
2015-09-11