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目的 本研究以具有补肝肾作用的中药材杜仲叶为原料，研制一款具有降脂作用的复合凝胶软糖，并探讨其降脂作用机制。方法 以杜仲叶汁为核心原料，结合现代食品工艺，添加明胶、果胶和魔芋粉作为胶基，通过单因素试验和Box-Behnken响应面实验，以感官评价和质构特性为评价指标开展综合评定，得到复合凝胶软糖的最佳制备工艺。同时，通过网络药理学研究探讨杜仲叶调节高脂血症的作用机制。结果 杜仲叶复合凝胶软糖最佳工艺条件为：复合凝胶软糖的最佳工艺条件为明胶-果胶-魔芋粉复合胶基配比20∶3∶3,杜仲叶汁添加量为148 mL,木糖醇添加量为44.5 g,柠檬酸添加量为0.66 g,在此条件下感官评分为83±2.45分。结论 杜仲叶汁可能通过槲皮素、(+)-儿茶素和山柰酚三种成分，经由卵巢类固醇生成、糖尿病心肌病、脂质与动脉粥样硬化、ErbB信号通路等途径发挥改善高脂血症的作用。
Abstract：Objective: To develop a composite gel gummy with potential lipid-lowering effects using Eucommia ulmoides leaves, a medicinal and edible traditional Chinese medicine traditionally used to tonify the liver and kidneys, and to explore the potential mechanisms underlying its lipid-lowering effects. Methods Eucommia ulmoides leaf juice was used as the principal raw material, with gelatin, pectin, and konjac powder incorporated as the composite gelling agents. Single-factor experiments and a Box-Behnken response surface design were employed to optimize the formulation and preparation process based on a comprehensive evaluation of sensory attributes and texture characteristics. Network pharmacology was subsequently used to investigate the potential mechanisms by which Eucommia ulmoides leaves may ameliorate hyperlipidemia.Results The optimal formulation of the Eucommia ulmoides leaf composite gel gummies consisted of a gelatin-pectin-konjac powder ratio of 20∶3∶3, 148 mL of Eucommia ulmoides leaf juice, 44.5 g of xylitol, and 0.66 g of citric acid. Under these optimized conditions, the sensory score was 83 ± 2.45.Conclusion Network pharmacology analysis suggested that Eucommia ulmoides leaf juice may exert beneficial effects against hyperlipidemia through active constituents including quercetin,(+)-catechin, and kaempferol, potentially involving pathways related to ovarian steroidogenesis, diabetic cardiomyopathy, lipid and atherosclerosis, and ErbB signaling.
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基本信息:
中图分类号:R285
引用信息:
[1]陈家龙,杨诚,李宇婷,等.Box-Behnken响应面优化杜仲叶复合凝胶软糖制备工艺及降血脂作用研究[J].微量元素与健康研究,2026,43(05):35-46.
基金信息:
贵州省2023年大学生创新创业训练计划项目(S202310662032); 贵州中医药大学博士启动基金(贵中医博启动[2023]5号); 中药民族药贵州省科技创新领军人才工作站(黔科合平台KXJZ[2024]034); 贵州省苗医药全省重点实验室(黔科合平台[2025]018)
2026-09-30
2026-09-30