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对一种新的药用矿物原料“铷矿物质”进行结构表征,并初步探讨其对帕金森病(parkinson's disease, PD)的治疗作用。通过扫描电镜、X射线粉末衍射、热重分析以及傅里叶红外光谱法等分析其结构组成与成分含量;采用行为分析仪分析帕金森病模型斑马鱼在给药前后的行为变化,利用荧光显微镜观察斑马鱼脑部多巴胺神经元的发育状况;“铷矿物质”的光学显微镜和扫描电镜图呈白色或乳白色的不规则碎片或碎块状晶体;X射线粉末衍射表明“铷矿物质”的主要成分为[Na0.98Ca0.02][Al1.02Si2.98O8]、Na[AlSi3O8]和K[AlSi3]O8,其余的微量元素(Rb、Fe、Ti、Ba等)占比1%左右,并绘制其特征指纹图谱;热重分析结果说明“铷矿物质”在高温下结构稳定;红外光谱图呈现出硅酸盐类金属矿物的典型特征吸收峰;体内实验初步表明“铷矿物质”能显著改善斑马鱼PD模型的多巴胺神经元损伤(P<0.05)。“铷矿物质”的发现可能对于帕金森病的治疗具有重要的调节作用。
Abstract:A newly identified medicinal mineral raw material, tentatively named “rubidium mineral, ” was structurally characterized and its preliminary therapeutic potential for Parkinson's disease(PD) was evaluated. Structural composition and elemental content were analyzed using scanning electron microscopy(SEM), X-ray powder diffraction(XRD), thermogravimetric analysis(TGA), and Fourier-transform infrared spectroscopy(FT-IR). Behavioral changes in a zebrafish PD model were assessed with an automated behavior-tracking system before and after administration of the mineral, and dopaminergic neuron development in the zebrafish brain was examined via fluorescence microscopy. Optical and SEM observations revealed the mineral as irregular white or off-white crystalline fragments. XRD analysis indicated that the main components of the material are [Na0.98Ca0.02][Al1.02Si2.98O8],Na[AlSi3O8], and K[AlSi3]O8, along with approximately 1% trace elements such as Rb, Fe, Ti, and Ba, and a characteristic fingerprint diffraction profile was established. TGA demonstrated structural stability at high temperatures, while FT-IR spectra displayed absorption bands typical of silicate minerals. In vivo experiments showed that the mineral significantly ameliorated dopaminergic neuronal damage in the zebrafish PD model. These findings suggest that “rubidium mineral” may have promising regulatory effects in the treatment of Parkinson's disease.
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基本信息:
DOI:
中图分类号:R914
引用信息:
[1]毛袁辉,覃琳茵,张文滨等.一种新的药用矿物原料“铷矿物质”的发现及成分分析[J].微量元素与健康研究,2025,42(04):22-29.
基金信息:
贵州中医药大学博士启动基金项目(贵中医启动[2025]01)